The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder
Identifieur interne : 000519 ( Main/Exploration ); précédent : 000518; suivant : 000520The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder
Auteurs : Y. K. Kim ; I-Y. Yoon ; J-M. Kim [Corée du Sud] ; S-H. Jeong ; K. W. Kim ; Y-K. Shin ; B. S. Kim ; S. E. KimSource :
- European Journal of Neurology [ 1351-5101 ] ; 2010-03.
English descriptors
Abstract
Background and purpose: The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is not clear despite its frequent association with Parkinson’s disease (PD). We investigated whether the nigrostriatal dopaminergic system is involved in the development of idiopathic RBD. Methods: Fourteen patients with RBD, 14 patients with PD and 12 normal controls were included in the study. The diagnosis of RBD was confirmed on polysomnography. All the participants performed single‐photon emission computed tomography imaging 3 h after injection of [123I]FP‐CIT. During REM sleep of the RBD patients, each 30‐s epoch was rated as ‘tonic’ when there was at least 50% of tonically maintained chin electromyography (EMG) activity in the epoch. Phasic EMG activities were calculated as the percentage of 3‐s mini‐epoch containing phasic EMG events (leg and chin, separately). Results: The RBD patients showed a trend of lower binding in the striatum than the normal controls (P = 0.07), and the significance was revealed in the putamen (P = 0.02). However, in 11 individual cases of the 14 RBD patients, the dopamine transporter (DAT) densities in the putamen still remained within the normal range. In the RBD patients, there was no correlation between EMG activities and DAT densities. Conclusions: Nigrostriatal dopaminergic degeneration could be a part of the pathogenesis of RBD, but not essential for the development of RBD. The lack of correlation between RBD severity and DAT densities suggests that another pathogenic process not related to nigrostriatal dopaminergic transmission may be implicated in RBD.
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DOI: 10.1111/j.1468-1331.2009.02854.x
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S. Kim</name></author><author><name sortKey="Kim, S E" sort="Kim, S E" uniqKey="Kim S" first="S. E." last="Kim">S. E. Kim</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C8B257239D23F8995FF19396BFCF15FA8EBB9E38</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1468-1331.2009.02854.x</idno><idno type="url">https://api.istex.fr/document/C8B257239D23F8995FF19396BFCF15FA8EBB9E38/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002028</idno><idno type="wicri:Area/Main/Curation">001D29</idno><idno type="wicri:Area/Main/Exploration">000519</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder</title><author><name sortKey="Kim, Y K" sort="Kim, Y K" uniqKey="Kim Y" first="Y. K." last="Kim">Y. K. Kim</name><affiliation><wicri:noCountry code="no comma">Departments of Nuclear Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Yoon, I" sort="Yoon, I" uniqKey="Yoon I" first="I-Y." last="Yoon">I-Y. Yoon</name><affiliation><wicri:noCountry code="no comma">Neuropsychiatry</wicri:noCountry></affiliation></author><author><name sortKey="Kim, J" sort="Kim, J" uniqKey="Kim J" first="J-M." last="Kim">J-M. Kim</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurology, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Jeong, S" sort="Jeong, S" uniqKey="Jeong S" first="S-H." last="Jeong">S-H. Jeong</name><affiliation><wicri:noCountry code="no comma">Neuropsychiatry</wicri:noCountry></affiliation></author><author><name sortKey="Kim, K W" sort="Kim, K W" uniqKey="Kim K" first="K. W." last="Kim">K. W. Kim</name><affiliation><wicri:noCountry code="no comma">Neuropsychiatry</wicri:noCountry></affiliation></author><author><name sortKey="Shin, Y" sort="Shin, Y" uniqKey="Shin Y" first="Y-K." last="Shin">Y-K. Shin</name><affiliation><wicri:noCountry code="no comma">Departments of Nuclear Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Kim, B S" sort="Kim, B S" uniqKey="Kim B" first="B. S." last="Kim">B. S. Kim</name><affiliation><wicri:noCountry code="no comma">Departments of Nuclear Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Kim, S E" sort="Kim, S E" uniqKey="Kim S" first="S. E." last="Kim">S. E. Kim</name><affiliation><wicri:noCountry code="no comma">Departments of Nuclear Medicine</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-03">2010-03</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="487">487</biblScope><biblScope unit="page" to="492">492</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">C8B257239D23F8995FF19396BFCF15FA8EBB9E38</idno><idno type="DOI">10.1111/j.1468-1331.2009.02854.x</idno><idno type="ArticleID">ENE2854</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>FP‐CIT SPECT</term><term>REM sleep behavior disorder</term><term>dopamine transporter</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and purpose: The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is not clear despite its frequent association with Parkinson’s disease (PD). We investigated whether the nigrostriatal dopaminergic system is involved in the development of idiopathic RBD. Methods: Fourteen patients with RBD, 14 patients with PD and 12 normal controls were included in the study. The diagnosis of RBD was confirmed on polysomnography. All the participants performed single‐photon emission computed tomography imaging 3 h after injection of [123I]FP‐CIT. During REM sleep of the RBD patients, each 30‐s epoch was rated as ‘tonic’ when there was at least 50% of tonically maintained chin electromyography (EMG) activity in the epoch. Phasic EMG activities were calculated as the percentage of 3‐s mini‐epoch containing phasic EMG events (leg and chin, separately). Results: The RBD patients showed a trend of lower binding in the striatum than the normal controls (P = 0.07), and the significance was revealed in the putamen (P = 0.02). However, in 11 individual cases of the 14 RBD patients, the dopamine transporter (DAT) densities in the putamen still remained within the normal range. In the RBD patients, there was no correlation between EMG activities and DAT densities. Conclusions: Nigrostriatal dopaminergic degeneration could be a part of the pathogenesis of RBD, but not essential for the development of RBD. The lack of correlation between RBD severity and DAT densities suggests that another pathogenic process not related to nigrostriatal dopaminergic transmission may be implicated in RBD.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><noCountry><name sortKey="Jeong, S" sort="Jeong, S" uniqKey="Jeong S" first="S-H." last="Jeong">S-H. Jeong</name><name sortKey="Kim, B S" sort="Kim, B S" uniqKey="Kim B" first="B. S." last="Kim">B. S. Kim</name><name sortKey="Kim, K W" sort="Kim, K W" uniqKey="Kim K" first="K. W." last="Kim">K. W. Kim</name><name sortKey="Kim, S E" sort="Kim, S E" uniqKey="Kim S" first="S. E." last="Kim">S. E. Kim</name><name sortKey="Kim, Y K" sort="Kim, Y K" uniqKey="Kim Y" first="Y. K." last="Kim">Y. K. Kim</name><name sortKey="Shin, Y" sort="Shin, Y" uniqKey="Shin Y" first="Y-K." last="Shin">Y-K. Shin</name><name sortKey="Yoon, I" sort="Yoon, I" uniqKey="Yoon I" first="I-Y." last="Yoon">I-Y. Yoon</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Kim, J" sort="Kim, J" uniqKey="Kim J" first="J-M." last="Kim">J-M. Kim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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